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The amygdala has traditionally been associated with fear, mediating the impact of negative emotions on memory. However, this view does not fully encapsulate the function of the amygdala, nor the impact that processing in this structure has on the motivational limbic corticostriatal circuitry of which it is an important structure. Here we discuss the interactions between different amygdala nuclei with cortical and striatal regions involved in motivation; interconnections and parallel circuitries that have become increasingly understood in recent years.

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Appetitive-searching reward-seeking and distress-avoiding misery-fleeing behavior are essential for all free moving animals to stay alive and to have offspring. Therefore, even the oldest ocean-dwelling animal creatures, living about million years ago and human ancestors, must have been capable of generating these behaviors. The current article describes the evolution of the forebrain with special reference to the development of the misery-fleeing system.

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As a child, Kay Tye was immersed in a life of science. Today, Tye runs her own neuroscience lab at MIT. Under large black lights reminiscent of a fashion shoot, she and her team at the Picower Institute for Learning and Memory can observe how mice behave when particular brain circuits are turned on or off.

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The reward system is a group of neural structures responsible for incentive salience i. Primary rewards are a class of rewarding stimuli which facilitate the survival of one's self and offspringand include homeostatic e. Survival for most animal species depends upon maximizing contact with beneficial stimuli and minimizing contact with harmful stimuli.

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In Freud's psychoanalytic theory of personality, the pleasure principle is the driving force of the id that seeks immediate gratification of all needs, wants and urges. In other words, the pleasure principle strives to fulfill our most basic and primitive urges, including hunger, thirst, anger, and sex. When these needs are not met, the result is a state of anxiety or tension.

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